On Tuesday, November 4, 2025, at around 5:15 p.m. Eastern, UPS Flight 2976 crashed shortly after takeoff from Louisville Muhammad Ali International Airport in Kentucky. The cargo jet, bound for Honolulu, reportedly failed to gain altitude, reaching just 175 feet before descending rapidly. Eyewitnesses described flames on the left wing and engine moments before impact.

The MD-11F aircraft, registered as N259UP, was first flown in 1991 and converted to cargo use before joining UPS in 2006. At 34 years old, it was nearing the upper range of operational age for commercial airframes. The MD-11 model has a complex handling reputation, and the plane’s heavy fuel load for the transpacific route increased the explosion risk upon crash.

Authorities confirmed at least three fatalities and eleven injuries, likely including the three crew members onboard. The crash struck an industrial zone beyond the runway, damaging a petroleum-recycling facility and an auto-parts warehouse. A shelter-in-place order was issued for a five-mile radius due to smoke and possible chemical hazards.

The location of the crash—just outside UPS’s massive Worldport hub—caused immediate operational shutdowns. Louisville is the company’s central distribution point, meaning delays could ripple through global supply chains and e-commerce networks.

The FAA and NTSB have opened a full investigation. Early focus areas include possible mechanical failure in the left engine, aircraft maintenance records, fuel distribution, pilot response, and ground safety procedures.

Investigators will review the flight-data and cockpit-voice recorders once recovered. They will also examine whether recent maintenance or deferred repairs contributed to the incident.

UPS has pledged full cooperation with federal agencies and is assessing the impact on its logistics operations.

As officials continue recovery efforts, the nation watches for answers—seeking to understand how a routine departure turned into a tragedy within moments.